Colorado (USA) is 2,204 times larger than San Francisco.
Colorado is a U.S. state encompassing most of the Southern Rocky Mountains as well as the northeastern portion of the Colorado Plateau and the western edge of the Great Plains. Colorado is part of the Western United States, the Southwestern United States, and the Mountain States. Wikipedia
Area: 122 km2 calculated
San Francisco, officially the City and County of San Francisco, is the cultural center and a leading financial hub of the San Francisco Bay Area and Northern California. Wikipedia