Indiana (USA) is 578 times larger than Columbia, Missouri.
Indiana is a U.S. state located in the midwestern and Great Lakes regions of North America. Indiana is the 38th largest by area and the 16th most populous of the 50 United States. Indiana is the least extensive state in the contiguous United States west of the Appalachian Mountains. Wikipedia
Area: 161 km2 calculated
Columbia is a city of 115,276 people in Missouri, a state of the American Midwest. Founded in 1818 as the county seat of Boone County and home to the University of Missouri, it is the principal municipality of the Columbia Metropolitan Area, the fourth most populous urban area in Missouri. Wikipedia