Huntsville is a city located primarily in Madison County in the central part of the far northern region of the State of Alabama. Huntsville is the county seat of Madison County. The city extends west into neighboring Limestone County. Huntsville's population was 180,105 as of the 2010 census. Wikipedia

Knoxville is a city in the U.S. state of Tennessee, and the county seat of Knox County. The city had a population of 178,874 as of the 2010 census and an estimated population of 183,270 in 2013, making it the state's third largest city. Wikipedia