Cape Coral, Florida is 2.4 times larger than San Francisco.
Area: 298 km2 calculated
Cape Coral is a city located in Lee County, Florida, United States, on the Gulf of Mexico. Founded in 1957 and developed as a master-planned, pre-platted community, the city grew to a population of 154,305 by the year 2010. Wikipedia
Area: 122 km2 calculated
San Francisco, officially the City and County of San Francisco, is the cultural center and a leading financial hub of the San Francisco Bay Area and Northern California. Wikipedia