Fort Wayne, Indiana is 2.1 times larger than Lafayette, Louisiana.
Area: 287 km2 calculated
Fort Wayne is a city in the U.S. state of Indiana and the county seat of Allen County. The population was 256,496 as of the 2013 Census estimate making it the 76th largest city in the United States and the second largest in Indiana after Indianapolis. Wikipedia
Area: 138 km2 calculated
Lafayette is a city located along the Vermilion River in southwestern Louisiana. The city of Lafayette is the fourth-largest in the state, with a population of 120,623 at the 2010 census. The combined statistical area of Lafayette–Opelousas-Morgan City was 611,774 according to 2012 estimates. Wikipedia