Des Moines, Iowa is 3.5 times larger than Syracuse, New York.
Area: 235 km2 calculated
Des Moines is the capital and the most populous city in the U.S. state of Iowa. It is also the county seat of Polk County. A small portion of the city extends into Warren County. It was incorporated on September 22, 1851, as Fort Des Moines which was shortened to "Des Moines" in 1857. Wikipedia
Area: 66 km2 calculated
Syracuse is a city in, and the county seat of, Onondaga County, New York, United States. It is the largest U.S. city with the name "Syracuse", and is the fifth most populous city in the state of New York. Wikipedia