Tucson, Arizona is 2.5 times larger than Des Moines, Iowa.
Area: 235 km2 calculated
Des Moines is the capital and the most populous city in the U.S. state of Iowa. It is also the county seat of Polk County. A small portion of the city extends into Warren County. It was incorporated on September 22, 1851, as Fort Des Moines which was shortened to "Des Moines" in 1857. Wikipedia
Area: 590 km2 calculated
Tucson is a city in and the county seat of Pima County, Arizona, United States, and home to the University of Arizona. The 2010 United States Census puts the city's population at 520,116, while the 2013 estimated population of the entire Tucson metropolitan area was 996,544. Wikipedia