Minneapolis is 24% larger than San Francisco.
Area: 151 km2 calculated
Minneapolis, officially the City of Minneapolis, is the county seat of Hennepin County, and largest of the Twin Cities, the 14th-largest metropolitan area in the United States, containing approximately 3.8 million residents. Wikipedia
Area: 122 km2 calculated
San Francisco, officially the City and County of San Francisco, is the cultural center and a leading financial hub of the San Francisco Bay Area and Northern California. Wikipedia