St. Louis is 2.6 times larger than Syracuse, New York.
Area: 170 km2 calculated
St. Louis is an independent city and a major United States port in eastern Missouri. The city reaches the western banks of the Mississippi River, which forms Missouri's eastern border with Illinois. At the 2010 census, St. Wikipedia
Area: 66 km2 calculated
Syracuse is a city in, and the county seat of, Onondaga County, New York, United States. It is the largest U.S. city with the name "Syracuse", and is the fifth most populous city in the state of New York. Wikipedia