Columbia is a city of 115,276 people in Missouri, a state of the American Midwest. Founded in 1818 as the county seat of Boone County and home to the University of Missouri, it is the principal municipality of the Columbia Metropolitan Area, the fourth most populous urban area in Missouri. Wikipedia

Huntsville is a city located primarily in Madison County in the central part of the far northern region of the State of Alabama. Huntsville is the county seat of Madison County. The city extends west into neighboring Limestone County. Huntsville's population was 180,105 as of the 2010 census. Wikipedia