Columbia is a city of 115,276 people in Missouri, a state of the American Midwest. Founded in 1818 as the county seat of Boone County and home to the University of Missouri, it is the principal municipality of the Columbia Metropolitan Area, the fourth most populous urban area in Missouri. Wikipedia

St. Louis is an independent city and a major United States port in eastern Missouri. The city reaches the western banks of the Mississippi River, which forms Missouri's eastern border with Illinois. At the 2010 census, St. Wikipedia