Columbia is a city of 115,276 people in Missouri, a state of the American Midwest. Founded in 1818 as the county seat of Boone County and home to the University of Missouri, it is the principal municipality of the Columbia Metropolitan Area, the fourth most populous urban area in Missouri. Wikipedia

Columbus is the capital of and the largest city in the U.S. state of Ohio. It is the 15th largest city in the United States with a population of 822,553. It is the core city of the Columbus, OH Metropolitan Statistical Area, which encompasses a ten county area. Wikipedia