Henderson, Nevada is 2.3 times larger than San Francisco.
Area: 283 km2 calculated
Henderson, officially the City of Henderson, is a city in Clark County, Nevada. It is the second largest city in Nevada, after Las Vegas, with an estimated population of 265,679 in 2012. The city is part of the Las Vegas metropolitan area, which spans the entire Las Vegas Valley. Wikipedia
Area: 122 km2 calculated
San Francisco, officially the City and County of San Francisco, is the cultural center and a leading financial hub of the San Francisco Bay Area and Northern California. Wikipedia