Knoxville is a city in the U.S. state of Tennessee, and the county seat of Knox County. The city had a population of 178,874 as of the 2010 census and an estimated population of 183,270 in 2013, making it the state's third largest city. Wikipedia

Pittsburgh is the seat of Allegheny County and with a population of 305,841 is the second-largest city in the U.S. state of Pennsylvania. With a metropolitan CSA population of 2,659,937, it is the largest in both the Ohio Valley and Appalachia and the 20th-largest in the U.S. Wikipedia