Pittsburgh is 2.6 times larger than Manhattan (NYC borough).
Area: 59 km2 calculated
Manhattan is the most densely populated of the five boroughs of New York City. The borough is coterminous with New York County, an original county of the U.S. state of New York. Wikipedia
Area: 153 km2 calculated
Pittsburgh is the seat of Allegheny County and with a population of 305,841 is the second-largest city in the U.S. state of Pennsylvania. With a metropolitan CSA population of 2,659,937, it is the largest in both the Ohio Valley and Appalachia and the 20th-largest in the U.S. Wikipedia